European Headache Federation recommendations for neurologists managing giant cell arteritis.

Mollan, S P, Paemeleire, K, Versijpt, J, Luqmani, R and Sinclair, A J (2020) European Headache Federation recommendations for neurologists managing giant cell arteritis. The journal of headache and pain, 21 (1). p. 28. ISSN 1129-2377.


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Giant cell arteritis (GCA) remains a medical emergency because of the risk of sudden irreversible sight loss and rarely stroke along with other complications. Because headache is one of the cardinal symptoms of cranial GCA, neurologists need to be up to date with the advances in investigation and management of this condition. The aim of this document by the European Headache Federation (EHF) is to provide an evidence-based and expert-based recommendations on GCA.


The working group identified relevant questions, performed systematic literature review and assessed the quality of available evidence, and wrote recommendations. Where there was not a high level of evidence, the multidisciplinary (neurology, ophthalmology and rheumatology) group recommended best practice based on their clinical experience.


Across Europe, fast track pathways and the utility of advanced imaging techniques are helping to reduce diagnostic delay and uncertainty, with improved clinical outcomes for patients. GCA is treated with high dose glucocorticoids (GC) as a first line agent however long-term GC toxicity is one of the key concerns for clinicians and patients. The first phase 2 and phase 3 randomised controlled trials of Tocilizumab, an IL-6 receptor antagonist, have been published. It is now been approved as the first ever licensed drug to be used in GCA.


The present article will outline recent advances made in the diagnosis and management of GCA.

Item Type: Article
Subjects: WL Nervous system. Neurology
WW Eyes. Ophthalmology
Divisions: Ambulatory Care > Ophthalmology
Emergency Services > Neurology
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Depositing User: Mr Philip O'Reilly
Date Deposited: 20 Mar 2020 15:19
Last Modified: 20 Mar 2020 15:19

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