High incidence of Hepatitis C virus infection observed in the PROUD study of HIV pre-exposure prophylaxis.

Desai, Monica, White, Ellen, Vora, Nina, Gilson, Richard, Lacey, Charles, Gafos, Mitzy, Clarke, Amanda, Sullivan, Ann, White, David, Fox, Julie, Piontkowsky, David, McCormack, Sheena and Dunn, David T (2020) High incidence of Hepatitis C virus infection observed in the PROUD study of HIV pre-exposure prophylaxis. Journal of viral hepatitis. ISSN 1365-2893. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jv...

Abstract

HIV negative men who have sex with men (MSM) who access pre-exposure prophylaxis (PrEP) report sexual behaviours that could place them at high risk of hepatitis C virus infection (HCV). We report HCV prevalence and incidence from the PROUD trial of PrEP.PROUD was an open-label, wait-list design randomised trial of HIV PrEP for MSM.Participants were recruited between November 2012 and April 2014, and follow-up continued to October 2016. Initial HCV testing followed national guidelines, with screening "on indication", but was replaced by routine quarterly screening in the latter part of the study.We estimated HCV seroprevalence at enrolment and incidence overall and according to calendar year.544 participants were recruited to PROUD. 133 (24.4%) were screened for HCV at enrolment, and 490 (90.1%) were tested at least once during follow-up. Seroprevalence at enrolment was 2.1% (11/530; 95% CI: 1.0-3.7%). Median follow-up time was 2.6 (IQR: 2.1-3.0) years and total follow-up of 1188.8 person years (PY). Twenty-five participants had a new HCV infection during the trial, yielding an incidence rate of 2.1 per 100 PY (25/1188.8; 95% CI: 1.4-3.1), of which three were re-infections. There was some evidence that HCV incidence increased over calendar time (P-value for trend=0.09), reaching an estimated 4.0 per 100 PY (95% CI: 2.0-8.1)in 2016. In conclusion, participants in PROUD had a high, and possibly increasing, incidence of HCV infection. This high incidence of HCV supports the 2018 BHIVA/BASHH recommendation for quarterly HCV testing among HIV-negative MSM using PrEP in the UK.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WC Communicabable diseases
WI Digestive system. Gastroenterology
Divisions: Clinical Support > Infectious Diseases
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Depositing User: Mrs Semanti Chakraborty
Date Deposited: 10 Apr 2020 16:21
Last Modified: 10 Apr 2020 16:21
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2987

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