A review of retroperitoneal liposarcoma genomics.

Tyler, Robert, Wanigasooriya, Kasun, Taniere, Philippe, Almond, Max, Ford, Samuel, Desai, Anant and Beggs, Andrew (2020) A review of retroperitoneal liposarcoma genomics. Cancer treatment reviews, 86. p. 102013. ISSN 1532-1967. Available in full text to all UHB Athens accounts holders via OpenAthens.

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Official URL: https://linkinghub.elsevier.com/retrieve/pii/S0305...


Retroperitoneal liposarcomas are rare tumours that carry a poorer prognosis than their extremity counterparts. Within their subtypes - well differentiated (WDL), dedifferentiated (DDL), myxoid (MLS) and pleomorphic (PLS) - they exhibit a diverse genomic landscape. With recent advances in next generation sequencing, the number of studies exploring this have greatly increased. The recent literature has deepened our understanding of the hallmark MDM2/CDK4 amplification in WDL/DDL and addressed concerns about toxicity and resistance when targeting this. The FUS-DDIT3 fusion gene remains the primary focus of interest in MLS with additional potential targets described. Whole genome sequencing has driven identification of novel genes and pathways implicated in WDL/DDL outside of the classic 12q13-15 amplicon. Due to their rarity; anatomical location and histologic subtype are infrequently mentioned when reporting the results of these studies. Reports can include non-adipogenic or extremity tumours, making it difficult to draw specific retroperitoneal conclusions. This narrative review aims to provide a summary of retroperitoneal liposarcoma genomics and the implications for therapeutic targeting.

Item Type: Article
Additional Information: Available in full text to all UHB Athens accounts holders via OpenAthens.
Subjects: QZ Pathology. Oncology
Divisions: Planned IP Care > Oncology and Clinical Haematology
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Depositing User: Mr Philip O'Reilly
Date Deposited: 17 Apr 2020 14:50
Last Modified: 17 Apr 2020 14:50
URI: http://www.repository.uhblibrary.co.uk/id/eprint/2994

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