Vitamin D deficiency is not associated with graft versus host disease after hematopoietic stem cell transplantation: A meta-analysis.

Chiengthong, Kanhatai, Cheungpasitporn, Wisit, Thongprayoon, Charat, Lertjitbanjong, Ploypin, Cato, Liam D, Bathini, Tarun, Ungprasert, Patompong, Mao, Michael A and Chokesuwattanaskul, Ronpichai (2020) Vitamin D deficiency is not associated with graft versus host disease after hematopoietic stem cell transplantation: A meta-analysis. Journal of evidence-based medicine. ISSN 1756-5391. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

OBJECTIVE

Vitamin D status plays an important role in immunoregulation, and a deficiency is believed to be related to Graft Versus Host Disease (GVHD) in patients after hematopoietic stem cell transplantation (HSCT). We aim to study the association between vitamin D deficiency and GVHD after HSCT.

METHODS

A literature search was conducted utilizing MEDLINE, EMBASE, and The Cochrane Library Database from inception to July 2019. Eligible studies were required to be clinical trials or observational studies (cohort, case-control, or cross-sectional studies); provide data to calculate the odds ratios (OR) of GVHD in HSCT patients with vitamin D deficiency. Two reviewers independently extracted the data and assessed the risk of bias. Pooled odds ratios (OR) with 95% confidence interval (CI) were estimated using random-effects meta-analysis through the Comprehensive Meta-Analysis 3.3 software.

RESULTS

In total, 8 observational studies consisting of 1335 HSCT patients were enrolled in this systematic review. Overall, there was no significant association between vitamin D deficiency and acute GVHD (OR = 1.06, 95% CI 0.74-1.53, P > 0.05). There was no significant association between vitamin D deficiency and chronic GVHD (OR = 1.75, 95% CI 0.72-4.26, P > 0.05). Funnel plots and Egger regression asymmetry test were performed and showed no publication bias.

CONCLUSION

There is not a statistically significant association between vitamin D deficiency and neither acute nor chronic GVHD.

Item Type:	Article
Additional Information:	This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects:	WH Haemic and lymphatic systems. Haematology
Related URLs:	https://www.ncbi.nlm.nih.gov/pubmed/3236...
Depositing User:	Mrs Yolande Brookes
Date Deposited:	15 May 2020 15:47
Last Modified:	15 May 2020 15:57
URI:	http://www.repository.uhblibrary.co.uk/id/eprint/3086

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