Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for PD-L1 Testing In Non-Small Cell Lung Cancer.

Perrotta, Fabio, Nankivell, Matthew, Adizie, Bhavani, Maqsood, Usman, Elshafi, Mohamed, Jafri, Syeda, Lerner, Andrew D, Woolhouse, Ian, Munavvar, Mohammed, Evison, Matthew, Booton, Richard, Baldwin, David R, Janes, Samuel M, Kerr, Keith M, Bianco, Andrea, Yarmus, Lonny and Navani, Neal (2020) Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for PD-L1 Testing In Non-Small Cell Lung Cancer. Chest. ISSN 1931-3543. (In Press) This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

RATIONALE

PD-L1 expression on cancer cells is a clinically important biomarker to select NSCLC patients for treatment with PD-1/PD-L1 inhibitors. Clinical trials of immunotherapy in patients with non-small cell lung cancer have required histology for PD-L1 testing, while in clinical practice cytology samples are commonly acquired in patients with advanced disease.

OBJECTIVES

This study investigates sampling adequacy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for PD-L1 testing when compared to other methods. Furthermore, the relationship between clinico-pathological characteristics and PD-L1 expression in the study population have been examined.

METHODS

Five hundred seventy-seven NSCLC specimens were analysed from consecutive patients with NSCLC across six centres in United Kingdom and one in the United States between January 2015 and December 2016.

MAIN RESULTS

In the EBUS-TBNA group (189 specimens), the overall percentage of patients with successful PD-L1 testing was 94.7%. There was no significant difference in sampling adequacy with other methods of tissue acquisition. Older subjects had higher failure rates of PD-L1 testing (OR= 1.06, p=0.008). In multivariate analysis, advanced N-stage (p=0.048) and presence of brain metastasis (p<0.001) were associated with high PD-L1 expression.

CONCLUSION

This large multicenter study shows that EBUS-TBNA provides samples adequate for PD-L1 testing and that advanced N stage and the presence of brain metastasis are associated with high PD-L1 expression.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WF Respiratory system. Respiratory medicine
WN Medical imaging. Radiology
Divisions: Planned IP Care > Respiratory Medicine
Related URLs:
Depositing User: Mrs Yolande Brookes
Date Deposited: 28 May 2020 15:10
Last Modified: 28 May 2020 15:10
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3118

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