Longitudinal development of PHOMS suggest a novel pathological pathway in MS.

Petzold, Axel, Coric, Danko, Balk, Lisanne J, Hamann, Steffen, Uitdehaag, Bernard M J, Denniston, Alastair K, Keane, Pearse A and Crabb, David P (2020) Longitudinal development of PHOMS suggest a novel pathological pathway in MS. Annals of neurology. ISSN 1531-8249. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/an...

Abstract

OBJECTIVE

Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS) are a new spectral domain Optical Coherence Tomography (OCT) finding.

METHODS

Prospective, longitudinal study. Patients (n=212) with MS (n=418 eyes), 59 healthy controls (HC, n=117 eyes) and 267 non-MS disease controls (534 eyes). OCT and Diffusion Tensor Imaging.

RESULTS

There were no PHOMS in HC eyes (0/117, 0%). The prevalence of PHOMS was significantly higher in patients with MS (34/212, p=0.001) and MS eyes (45/418, p=0.0002) if compared to HC (0/59, 0/117). The inter-rater agreement for PHOMS was 97.9%, kappa 0.951. PHOMS were present in 16% of patients with relapsing remitting, 16% of patients with progressive and 12% of patients with secondary progressive disease course (2% of eyes). There was no relationship of PHOMS with age, disease duration, disease course, disability or disease modifying treatments. The fractional anisotropy of the optic radiations was lower in patients without PHOMS (0.814) if compared to patients with PHOMS (0.845, p=0.03). The majority of PHOMS remained stable, but increase in size and de novo development of PHOMS were also observed. In non-MS disease controls, PHOMS were observed in intracranial hypertension (62%), ODD (47%), anomalous optic discs (44%), isolated optic neuritis (19%) and optic atrophy (12%).

INTERPRETATION

These data suggest that PHOMS are a novel finding in MS pathology. Future research is needed to determine if development of PHOMS in MS is due to intermittently raised intracranial pressure or an otherwise impaired "glymphatic" outflow from eye to brain. This article is protected by copyright. All rights reserved.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WN Medical imaging. Radiology
WW Eyes. Ophthalmology
Divisions: Ambulatory Care > Ophthalmology
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Depositing User: Mrs Yolande Brookes
Date Deposited: 28 May 2020 15:38
Last Modified: 28 May 2020 15:38
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3119

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