Interventions for the management and prevention of sarcopenia in the critically ill: A systematic review.

Trethewey, Samuel P, Brown, Nicholas, Gao, Fang and Turner, Alice M (2019) Interventions for the management and prevention of sarcopenia in the critically ill: A systematic review. Journal of critical care, 50. pp. 287-295. ISSN 1557-8615. This article is available to all UHB staff and students through UHB Open Athens

Full text not available from this repository.
Official URL: https://www.sciencedirect.com/science/article/abs/...

Abstract

PURPOSE

In the critically ill, sarcopenia is associated with a variety of adverse outcomes however there is no consensus regarding its management. This study aimed to systematically review the evidence for interventions for the management and prevention of sarcopenia in critically ill patients.

MATERIALS AND METHODS

Bibliographic databases were searched according to pre-specified criteria (PROSPERO-CRD42018086271). Randomised controlled trials (RCTs) investigating interventions to preserve muscle mass and/or function in critically ill patients were included. Two independent authors selected the articles and assessed bias using the Cochrane Risk of Bias Tool.

RESULTS

Twenty-two eligible RCTs were identified comprising 2792 patients. Three main groups of interventions were implemented in these trials: neuromuscular electrical stimulation (NMES), exercise-based and nutritional. Both the interventions and outcomes measured varied significantly between studies. NMES was most frequently studied as an intervention to preserve muscle mass whilst exercise-based treatments were evaluated as interventions to preserve muscle function. There was significant variation in the efficacy of the interventions on sarcopenia markers and secondary outcomes.

CONCLUSIONS

NMES and exercise-based interventions may preserve muscle mass and function in patients with critical illness. There is a lack of consistency seen in the effects of these interventions. Further, large, high quality RCTs are required.

Item Type: Article
Additional Information: This article is available to all UHB staff and students through UHB Open Athens
Subjects: WB Practice of medicine > WB400 Intensive care
WT Geriatrics. Elderly care
Divisions: Clinical Support > Critical Care
Emergency Services > Acute Medicine and AMU
Emergency Services > Elderly
Related URLs:
Depositing User: Beth Connors
Date Deposited: 29 May 2020 14:31
Last Modified: 29 May 2020 14:31
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3122

Actions (login required)

View Item View Item