Early relapse after high-dose melphalan autologous stem cell transplant predicts inferior survival and is associated with high disease burden and genetically high-risk disease in multiple myeloma.

Bygrave, Ceri, Pawlyn, Charlotte, Davies, Faith, Craig, Zoe, Cairns, David, Hockaday, Anna, Jenner, Matthew, Cook, Gordon, Drayson, Mark T, Owen, Roger, Gregory, Walter, Morgan, Gareth, Jackson, Graham and Kaiser, Martin (2020) Early relapse after high-dose melphalan autologous stem cell transplant predicts inferior survival and is associated with high disease burden and genetically high-risk disease in multiple myeloma. British journal of haematology. ISSN 1365-2141. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/bj...

Abstract

Predicting patient outcome in multiple myeloma remains challenging despite the availability of standard prognostic biomarkers. We investigated outcome for patients relapsing early from intensive therapy on NCRI Myeloma XI. Relapse within 12 months of autologous stem cell transplant was associated with markedly worse median progression-free survival 2 (PFS2) of 18 months and overall survival (OS) of 26 months, compared to median PFS2 of 85 months and OS of 91 months for later relapsing patients despite equal access to and use of subsequent therapies, highlighting the urgent need for improved outcome prediction and early intervention strategies for myeloma patients.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WH Haemic and lymphatic systems. Haematology
WO Surgery
Divisions: Clinical Support > Immunology
Planned IP Care > Oncology and Clinical Haematology
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Depositing User: Mrs Yolande Brookes
Date Deposited: 19 Jun 2020 13:39
Last Modified: 19 Jun 2020 13:39
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3187

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