Reversal of Bioprosthetic Aortic Valve Thrombosis Using Rivaroxaban-A Case Report.

Sharma, Harish, Vetrugno, Vincenzo and Ludman, Peter (2020) Reversal of Bioprosthetic Aortic Valve Thrombosis Using Rivaroxaban-A Case Report. Frontiers in cardiovascular medicine, 7. p. 87. ISSN 2297-055X. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

Bioprosthetic valve thrombosis (BPVT) is a rare but recognized complication causing valve dysfunction. In subacute valve thrombosis, systemic oral anticoagulation is recommended. However, there is little data comparing the efficacy of warfarin and novel oral anticoagulant (NOAC) therapy in this setting. A patient developed subacute BPVT 11 years post-implantation. The patient was initially treated with warfarin for a period of 6 months, with limited effect. Following replacement of warfarin with rivaroxaban, there was significant reversal of the BPVT, as represented by a reduction in transaortic maximal velocity (Vmax) from 4.1 to 3 m/s over 7 months. Systemic oral anticoagulation can be an effective treatment for subacute valve thrombosis. Guidelines currently recommend warfarin as first line but NOACs can be considered in such patients and may be more effective than warfarin. Randomized controlled trials are required to further establish the optimal anticoagulation for patients with subacute BPVT.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WG Cardiovascular system. Cardiology
WH Haemic and lymphatic systems. Haematology
Divisions: Emergency Services > Cardiology
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Depositing User: Jamie Edgar
Date Deposited: 24 Jun 2020 11:47
Last Modified: 24 Jun 2020 11:47
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3200

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