Cell-in-Cell Structures in the Liver: A Tale of Four E's.

Davies, Scott P, Terry, Lauren V, Wilkinson, Alex L and Stamataki, Zania (2020) Cell-in-Cell Structures in the Liver: A Tale of Four E's. Frontiers in immunology, 11. p. 650. ISSN 1664-3224. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

[img] Text (PDF file format)
full - Published Version
Available under License Creative Commons Attribution 4.0.

Download (242kB)
Official URL: https://www.frontiersin.org/journals/immunology

Abstract

The liver is our largest internal organ and it plays major roles in drug detoxification and immunity, where the ingestion of extracellular material through phagocytosis is a critical pathway. Phagocytosis is the deliberate endocytosis of large particles, microbes, dead cells or cell debris and can lead to cell-in-cell structures. Various types of cell endocytosis have been recently described for hepatic epithelia (hepatocytes), which are non-professional phagocytes. Given that up to 80% of the liver comprises hepatocytes, the biological impact of cell-in-cell structures in the liver can have profound effects in liver regeneration, inflammation and cancer. This review brings together the latest reports on four types of endocytosis in the liver -efferocytosis, entosis, emperipolesis and enclysis, with a focus on hepatocyte biology.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QW Microbiology. Immunology
QZ Pathology. Oncology
WI Digestive system. Gastroenterology
Divisions: Planned IP Care > Gastroentrology
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 25 Jun 2020 10:21
Last Modified: 25 Jun 2020 10:21
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3201

Actions (login required)

View Item View Item