Treating age-related multimorbidity: the drug discovery challenge.

Ermogenous, Christos, Green, Charlotte, Jackson, Thomas, Ferguson, Michael and Lord, Janet M (2020) Treating age-related multimorbidity: the drug discovery challenge. Drug discovery today. ISSN 1878-5832.

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Patients with multimorbidities have shorter life expectancy and their clinical management is more complex and expensive for healthcare systems currently focused on treating single diseases. Given that age is the major risk factor for multimorbidity, the challenge of treating these patients will only increase in coming years. Here, we review the case for targeting the core processes that drive the ageing phenotype as a novel pharmaceutical approach to multimorbidity. There is growing evidence that targeting ageing mechanisms can reduce or delay age-related diseases in animal models, and the first reports of clinical trials are now appearing. Although these trials currently focus on repurposed drugs, we propose several novel targets that would more specifically target ageing processes and thereby reduce multimorbidity and polypharmacy in future generations.

Item Type: Article
Subjects: QV Pharmacology
WT Geriatrics. Elderly care
Divisions: Emergency Services > Elderly
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Depositing User: Mrs Yolande Brookes
Date Deposited: 02 Jul 2020 11:55
Last Modified: 02 Jul 2020 11:55

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