Bilateral acute anterior uveitis and iris atrophy caused by moxifloxacin.

Hui, Benjamin Tsun Kiu, Capewell, Nicholas, Ansari, Yousuf and Liu, Xiaoxuan (2020) Bilateral acute anterior uveitis and iris atrophy caused by moxifloxacin. BMJ case reports, 13 (6). ISSN 1757-790X. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://casereports.bmj.com/content/13/6/e233528.l...

Abstract

A 56-year-old paramedic was admitted to hospital and treated for severe pneumonia. Shortly after initiating antibiotic treatment (including moxifloxacin), he developed bilaterally painful eyes and was diagnosed with bilateral acute anterior uveitis (AAU). Three years later, he was referred to the ophthalmology clinic with bilateral iris transillumination suggesting iris atrophy and limited pupillary dilation, indicating iris sphincter muscle paralysis. AAU typically presents unilaterally. An onset of bilateral AAU is unusual and warrants investigation for underlying systemic cause. The fluoroquinolone moxifloxacin has been reported in a limited number of cases as a causative agent of bilateral AAU and iris atrophy. This case provides additional supporting evidence that moxifloxacin may cause degradation of collagen and iris muscle in the eye, as well as elsewhere in the body, such as in blood vessels. Additionally, we present novel anterior segment ocular imaging (using optical coherence tomography) demonstrating the ability to detect iris atrophy using non-invasive imaging.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QV Pharmacology
WW Eyes. Ophthalmology
Divisions: Ambulatory Care > Ophthalmology
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Depositing User: Mrs Yolande Brookes
Date Deposited: 09 Jul 2020 13:51
Last Modified: 09 Jul 2020 13:51
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3254

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