Characterising the impact of pneumonia on outcome in non-small cell lung cancer: identifying preventative strategies.

Patel, Akshay J, Nightingale, Peter, Naidu, Babu, Drayson, Mark T, Middleton, Gary W and Richter, Alex (2020) Characterising the impact of pneumonia on outcome in non-small cell lung cancer: identifying preventative strategies. Journal of thoracic disease, 12 (5). pp. 2236-2246. ISSN 2072-1439.

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Infections remain a part of the natural course of cancer, and lung cancer patients often present with some form of respiratory infection that can lead to their ultimate demise.


Data was gathered concerning all unplanned hospital admissions (UHAs) to our centre from three separate patient cohorts; non-small cell lung cancer (NSCLC) patients (cohort 1), "other cancer" patients (breast, prostate, colon) (cohort 2) and all non-cancer patients (cohort 3).


Across the three cohorts, there were 455, 1,190 and 54,158 individual patient UHAs to our centre respectively. Within the NSCLC cohort, 164 UHAs were as a direct result of pneumonia (36.0%), compared to 1.3% and 2.2% in the other two cohorts (P<0.0001). In-hospital mortality and length of hospital stay were significantly higher in the pneumonia sub-group of NSCLC patients only compared with the other two patient cohorts (P<0.0001 and P=0.011 respectively). Within the NSCLC cohort, Patient age, pneumococcal vaccination status, pneumonia admission, smoking status and specific tumour stages were identified as significant independent risk factors for in-hospital mortality. Odds ratios of 0.160 for positive vaccination status and 9.522 for pneumonia admission indicate that for NSCLC patients admitted to hospital with a pneumonia without previous pneumococcal vaccination in the last 5 years, the odds of death were almost 60-fold higher.


Vigilance for infection, early diagnosis with adequate assessment and efforts to identify a culprit organism should be a priority when faced with these patients. Infection prevention strategies should be further explored to address this high mortality risk in NSCLC.

Item Type: Article
Subjects: QW Microbiology. Immunology
WC Communicabable diseases
WF Respiratory system. Respiratory medicine
Divisions: Emergency Services > Cardiology
Planned IP Care > Thoracic Surgery
Related URLs:
Depositing User: Mrs Yolande Brookes
Date Deposited: 16 Jul 2020 12:26
Last Modified: 16 Jul 2020 12:26

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