Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques.

Stamatopoulos, Konstantinos, Karandikar, Sharad, Goldstein, Mark, O'Farrell, Connor, Marciani, Luca, Sulaiman, Sarah, Hoad, Caroline L, Simmons, Mark J H and Batchelor, Hannah K (2020) Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques. Pharmaceutics, 12 (7). ISSN 1999-4923.

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Official URL: https://www.mdpi.com/1999-4923/12/7/659

Abstract

This work used in vivo MRI images of human colon wall motion to inform a biorelevant Dynamic Colon Model (DCM) to understand the interplay of wall motion, volume, viscosity, fluid, and particle motion within the colon lumen. Hydrodynamics and particle motion within the DCM were characterized using Positron Emission Tomography (PET) and Positron Emission Particle Tracking (PEPT), respectively. In vitro PET images showed that fluid of higher viscosity follows the wall motion with poor mixing, whereas good mixing was observed for a low viscosity fluid. PEPT data showed particle displacements comparable to the in vivo data. Increasing fluid viscosity favors the net forward propulsion of the tracked particles. The use of a floating particle demonstrated shorter residence times and greater velocities on the liquid surface, suggesting a surface wave that was moving faster than the bulk liquid. The DCM can provide an understanding of flow motion and behavior of particles with different buoyancy, which in turn may improve the design of drug formulations, whereby fragments of the dosage form and/or drug particles are suspended in the proximal colon.

Item Type: Article
Subjects: WI Digestive system. Gastroenterology
WN Medical imaging. Radiology
Divisions: Clinical Support > Radiology
Planned IP Care > General Surgery
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Depositing User: Mrs Yolande Brookes
Date Deposited: 24 Jul 2020 09:10
Last Modified: 24 Jul 2020 09:10
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3294

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