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Taylor, J, Hyare, J, Stelfox, P, Williams, M, Lees, R and Maley, M (2011) Multi-centre evaluation of pre-transfusional routine tests using 8-column format gel cards (DG Gel®). Transfusion medicine (Oxford, England), 21 (2). pp. 90-8. ISSN 1365-3148. This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login IDs
Full text not available from this repository.Abstract
BACKGROUND
Advances in immunohaematology laboratory practice to improve performance, cost-effectiveness and patient safety are desirable.
OBJECTIVES
To perform a multi-centre evaluation of the 8-column Grifols DG Gel(®) cards and reagent system to assess its performance, suitability and adaptability to the daily blood transfusion laboratory routine in the United Kingdom.
METHODS/MATERIALS
A total of 4281 immunohematological analyses {1825 ABO/D grouping, 1921 antibody screening, 75 Rh phenotyping and K antigen determination, 361 antibody identification and 99 neonates [ABO/D and DAT (direct anti-globulin test)]} were performed on 2255 specimens. All cases were run in parallel with the reference method of each laboratory (DiaMed-ID(®) cards or conventional tube technique in some cases).
RESULTS
Concordant results between Grifols DG Gel(®) system and the reference method were obtained in 97·7% of tests. For ABO grouping by the Grifols DG Gel(®) system, sensitivity was 99·95%, specificity was 99·96%, predictive positive value (PPV) was 99·89% and predictive negative value (PNV) was 99·98%. For D grouping, sensitivity was 99·78%, specificity was 100%, PPV was 100% and PNV was 99·78%. For antibody screening, sensitivity was 90·63%, specificity was 99·94%, PPV was 99·32% and PNV was 99·15%. Of the Rh subgroups and K types, results were 100% concordant. For antibody specificity detection, accuracy was 96·95% for Grifols DG Gel(®) system and 95·29% for DiaMed-ID(®) system. For the newborn tests, concordant results were obtained in 100% of ABO/D grouping and in 89·9% of DAT.
CONCLUSION
The Grifols DG Gel(®) 8-column system is reliable and safe for routine tests performed in the immunohaematology laboratory.
| Item Type: | Article |
|---|---|
| Additional Information: | This article is accessible to all HEFT staff and students via NHS Evidence www.evidence.nhs.uk by using their HEFT Athens login IDs |
| Subjects: | WH Haemic and lymphatic systems. Haematology |
| Divisions: | Clinical Support > Pathology |
| Related URLs: | |
| Depositing User: | Mr Philip O'Reilly |
| Date Deposited: | 25 Jun 2014 14:25 |
| Last Modified: | 25 Jun 2014 14:25 |
| URI: | http://www.repository.uhblibrary.co.uk/id/eprint/331 |
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