Emerging themes in idiopathic intracranial hypertension.

Grech, Olivia, Mollan, Susan P, Wakerley, Benjamin R, Alimajstorovic, Zerin, Lavery, Gareth G and Sinclair, Alexandra J (2020) Emerging themes in idiopathic intracranial hypertension. Journal of neurology. ISSN 1432-1459. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://www.springer.com/journal/415

Abstract

PURPOSE

Idiopathic intracranial hypertension (IIH) is a rare disorder characterised by raised intracranial pressure. The underlying pathophysiology is mostly unknown and effective treatment is an unmet clinical need in this disease. This review evaluates key emerging themes regarding disease characteristics, mechanisms contributing to raised intracranial pressure and advances in potential therapeutic targets.

FINDINGS

IIH is becoming more common, with the incidence rising in parallel with the global obesity epidemic. Current medical management remains centred around weight management, which is challenging. Metabolic investigations of patients have identified specific androgen profiles in cerebrospinal fluid (CSF), which suggest an endocrine dysfunction impacting CSF secretion in IIH. Glucagon-like peptide-1 (GLP-1) and 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) have been found to play a role in CSF dynamics in IIH and have formed the basis of the first clinical trials looking at new treatments.

CONCLUSIONS

Identification of novel molecular targets thought to underlie IIH pathology is now being translated to clinical trials.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WK Endocrine system. Endocrinology
WL Nervous system. Neurology
WW Eyes. Ophthalmology
Divisions: Emergency Services > Neurology
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 05 Aug 2020 09:14
Last Modified: 05 Aug 2020 09:14
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3338

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