Nuclease Therapy Improves Severe Fatigue in Primary Sjögren's Syndrome: A Randomized Clinical Trial.

Posada, James, Valadkhan, Saba, Burge, Daniel, Davies, Kristen, Tarn, Jessica, Casement, John, Jobling, Kerry, Gallagher, Peter, Wilson, Douglas, Barone, Francesca, Fisher, Benjamin A and Ng, Wan-Fai (2020) Nuclease Therapy Improves Severe Fatigue in Primary Sjögren's Syndrome: A Randomized Clinical Trial. Arthritis & rheumatology (Hoboken, N.J.). ISSN 2326-5205. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

Full text not available from this repository.
Official URL: http://onlinelibrary.wiley.com/journal/10.1002/(IS...

Abstract

OBJECTIVE

To assess the safety and efficacy of RSLV-132, an RNase Fc fusion protein in a phase II randomized, double-blind, placebo-controlled clinical trial in patients with primary Sjögren's syndrome (pSS).

METHODS

Thirty patients were randomized to receive intravenous RSLV-132 or placebo, weekly for two weeks then every two weeks for twelve weeks. Eight subjects received placebo and twenty received RSLV-132, 10 mg/kg. Clinical efficacy measures included the European League Against Rheumatism (EULAR) Sjögren's syndrome disease activity index (ESSDAI), EULAR Sjögren's syndrome patient reported index (ESSPRI), FACIT fatigue (FACIT-F), and profile of fatigue (ProF), and the digit symbol substitution test (DSST).

RESULTS

Patients randomized to RSLV-132, but not placebo, experienced clinically meaningful improvements in ESSPRI, FACIT-F, ProF, and DSST. This improvement was correlated with increased expression of selected interferon-inducible genes.

CONCLUSION

Administration of RSLV-132 improved severe fatigue in pSS patients as determined by four independent measures of fatigue.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WA Patients. Primary care. Medical profession. Forensic medicine
WE Musculoskeletal. Orthopaedics
Divisions: Ambulatory Care > Rheumatology
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 21 Aug 2020 13:35
Last Modified: 21 Aug 2020 13:35
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3371

Actions (login required)

View Item View Item