Unusual Presentation of Mammary Calciphylaxis in a Patient on Long-Standing Renal Dialysis.

Elghobashy, Maiar, Vaquas, Shams, Elshafie, Mona, Kaneri, Shekhar and Shaaban, Abeer M (2020) Unusual Presentation of Mammary Calciphylaxis in a Patient on Long-Standing Renal Dialysis. Pathobiology : journal of immunopathology, molecular and cellular biology. pp. 1-5. ISSN 1423-0291.

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Official URL: https://www.karger.com/Article/Abstract/508537



Calciphylaxis is a condition which involves ectopic deposition of calcium in arterioles of various organ systems. Here, we present a rare case of mammographic calcifications in a patient on long-standing renal dialysis.


This is a 57-year-old female who presented to breast clinic with unilateral severe pain and lumpiness of her breast. On mammography, calcifications were identified which were associated with focal lesions on ultrasound. An image-guided core biopsy showed numerous foci of histological calcification within a large area of fat necrosis. The location within arterioles was confirmed by CD31 immunohistochemistry. The diagnosis of fat necrosis with benign calcifications due to mammary calciphylaxis was made.


The hallmark of calciphylaxis is the deposition of calcium within small- to medium-sized vessel walls. This leads to ischaemia and necrosis of tissue. In the breast, only a few cases were reported in which patients presented with a necrotic lesion resembling carcinoma. These are reviewed in this report.

Item Type: Article
Subjects: WJ Urogenital system. Urology
WP Gynaecology. Women’s health
Divisions: Clinical Support > Pathology
Clinical Support > Radiology
Planned IP Care > General Surgery
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Depositing User: Mrs Yolande Brookes
Date Deposited: 26 Aug 2020 13:59
Last Modified: 26 Aug 2020 13:59
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3380

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