Inflammatory and Fibrogenic Factors in Proliferative Vitreoretinopathy Development.

Chaudhary, Rishika, Scott, Robert A H, Wallace, Graham, Berry, Martin, Logan, Ann and Blanch, Richard J (2020) Inflammatory and Fibrogenic Factors in Proliferative Vitreoretinopathy Development. Translational vision science & technology, 9 (3). p. 23. ISSN 2164-2591.

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Official URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC73578...

Abstract

Purpose

Proliferative vitreoretinopathy (PVR) occurs in 5%-10% of rhegmatogenous retinal detachment cases and is the principle cause for failure of retinal reattachment surgery. Although there are a number of surgical adjunctive agents available for preventing the development of PVR, all have limited efficacy. Discovering predictive molecular biomarkers to determine the probability of PVR development after retinal reattachment surgery will allow better patient stratification for more targeted drug evaluations.

Methods

Narrative literature review.

Results

We provide a summary of the inflammatory and fibrogenic factors found in ocular fluid samples during the development of retinal detachment and PVR and discuss their possible use as molecular PVR predictive biomarkers.

Conclusions

Studies monitoring the levels of the above factors have found that few if any have predictive biomarker value, suggesting that widening the phenotype of potential factors and a combinatorial approach are required to determine predictive biomarkers for PVR.

Translational Relevance

The identification of relevant biomarkers relies on an understanding of disease signaling pathways derived from basic science research. We discuss the extent to which those molecules identified as biomarkers and predictors of PVR relate to disease pathogenesis and could function as useful disease predictors. (http://www.umin.ac.jp/ctr/ number, UMIN000005604).

Item Type: Article
Subjects: WW Eyes. Ophthalmology
Divisions: Ambulatory Care > Ophthalmology
Related URLs:
Depositing User: Mrs Yolande Brookes
Date Deposited: 28 Aug 2020 15:04
Last Modified: 28 Aug 2020 15:04
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3388

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