Nelson's Syndrome: An Update.

Fountas, Athanasios and Karavitaki, Niki (2020) Nelson's Syndrome: An Update. Endocrinology and metabolism clinics of North America, 49 (3). pp. 413-432. ISSN 1558-4410. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

Nelson's syndrome (NS) is a condition which may develop in patients with Cushing's disease after bilateral adrenalectomy. Although there is no formal consensus on what defines NS, corticotroph tumor growth and/or gradually increasing ACTH levels are important diagnostic elements. Pathogenesis is unclear and well-established predictive factors are lacking; high ACTH during the first year after bilateral adrenalectomy is the most consistently reported predictive parameter. Management is individualized and includes surgery, with or without radiotherapy, radiotherapy alone, and observation; medical treatments have shown inconsistent results. A subset of tumors demonstrates aggressive behavior with challenging management, malignant transformation and poor prognosis.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WK Endocrine system. Endocrinology
Divisions: Ambulatory Care > Endocrinology
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Depositing User: Mrs Yolande Brookes
Date Deposited: 28 Aug 2020 15:39
Last Modified: 28 Aug 2020 15:39
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3390

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