Hartmann's procedure versus Intersphincteric APE (HiP Study):A Multicentre Prospective Cohort Study.

Fowler, Hayley, Clifford, Rachael, Sutton, Paul, Watson, Angus, Fearnhead, Nicola, Bach, Simon, Moran, Brendan, Rose, Azmina, Jackson, Richard and Vimalachandran, Dale (2020) Hartmann's procedure versus Intersphincteric APE (HiP Study):A Multicentre Prospective Cohort Study. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. ISSN 1463-1318.

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Official URL: https://onlinelibrary.wiley.com/doi/10.1111/codi.1...



In patients with low rectal cancer, it is occasionally necessary to avoid a low colo-anal anastomosis due to patient frailty or poor function. In such situations there are two alternative approaches: Hartmann's procedure [HP] or intersphincteric APE [IAPE]. There are little data to guide surgeons as to which of these two procedures is the safest. The aim of this study was to determine the surgical complication rates associated with each procedure.


This was a multicentre, non-randomised prospective cohort study of patients undergoing either HP or IAPE. The primary objective was to determine surgical complication rates. Secondary objectives included length of stay, time to adjuvant therapy and quality of life at 90 days.


179 patients were recruited between April 2016 and June 2019; approximately two thirds of patients underwent HP and one third IAPE. The overall complication rate was high in both groups: 54% [HP], 52% [IAPE]. Surgery specific complication rates were also high, but not significantly different: 43% [HP], 48% [IAPE]. The pelvic abscess rate in HP was 11% and was significantly higher in patients with a palpable staple line (15% vs 2%). There was a higher incidence of serious medical complications following IAPE[16% vs 5%], along with a reduction in 90-day QoL scores.


This is the largest prospective study comparingHP and IAPE in patients undergoing rectal cancer surgery where primary anastomosis is not deemed appropriate. With similar complication rates, these data support the ongoing use of either HP or IAPE in this patient group.

Item Type: Article
Subjects: WI Digestive system. Gastroenterology
Divisions: Planned IP Care > Gastroentrology
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Depositing User: Mrs Caroline Tranter
Date Deposited: 18 Sep 2020 13:40
Last Modified: 18 Sep 2020 13:40
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3442

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