Home parenteral nutrition in neuroendocrine tumour intestinal failure: improved quality of life and longevity.

Sagar, Vandana M, Shah, Tahir, Malhi, Hardip, Parkinson, Sharmalie, Shetty, Shishir and Cooper, Sheldon C (2020) Home parenteral nutrition in neuroendocrine tumour intestinal failure: improved quality of life and longevity. BMJ supportive & palliative care. ISSN 2045-4368. Available in full text via UHB OpenAthens

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Official URL: https://spcare.bmj.com/content/early/2020/09/11/bm...

Abstract

BACKGROUND

Neuroendocrine tumours (NETs) are neoplastic yet behave differently to typical cancers. Despite often being slow growing, they can lead to significant gastrointestinal complications including intestinal failure (IF). The use of home parenteral nutrition (HPN) in neoplastic conditions is rising, primarily for palliation and bridging through treatments for cancer, but remains a challenging decision with a paucity of high-grade evidence-based guidance.

METHODS

A retrospective analysis of patients with NET on HPN was performed. Data collected included the cause of IF, complications encountered with HPN and changes in nutritional assessments.

RESULTS

Eight patients were identified, all with metastatic NET. Median weight improved following HPN commencement and line sepsis was the sole complication. All patients had stabilisation and optimisation of nutritional and hydration status.

CONCLUSIONS

HPN is commenced to improve or maintain patients' nutritional status during often lifelong treatment. The principle aim in providing HPN was to improve survival and quality of life. While NETs are cancers, our case series demonstrates the potential of HPN to actively support longer term survival in the subgroup of patients who develop IF.

Item Type: Article
Additional Information: Available in full text via UHB OpenAthens
Subjects: WI Digestive system. Gastroenterology
Divisions: Planned IP Care > Gastroentrology
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Depositing User: Mr Philip O'Reilly
Date Deposited: 23 Sep 2020 13:10
Last Modified: 23 Sep 2020 13:10
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3466

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