Dynamic contrast-enhanced near-infrared spectroscopy using indocyanine green on moderate and severe traumatic brain injury: a prospective observational study.

Forcione, Mario, Yakoub, Kamal Makram, Chiarelli, Antonio Maria, Perpetuini, David, Merla, Arcangelo, Sun, Rosa, Sawosz, Piotr, Belli, Antonio and Davies, David James (2020) Dynamic contrast-enhanced near-infrared spectroscopy using indocyanine green on moderate and severe traumatic brain injury: a prospective observational study. Quantitative imaging in medicine and surgery, 10 (11). pp. 2085-2097. ISSN 2223-4292. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

Background

The care given to moderate and severe traumatic brain injury (TBI) patients may be hampered by the inability to tailor their treatments according to their neurological status. Contrast-enhanced near-infrared spectroscopy (NIRS) with indocyanine green (ICG) could be a suitable neuromonitoring tool.

Methods

Monitoring the effective attenuation coefficients (EAC), we compared the ICG kinetics between five TBI and five extracranial trauma patients, following a venous-injection of 5 mL of 1 mg/mL ICG, using two commercially available NIRS devices.

Results

A significantly slower passage of the dye through the brain of the TBI group was observed in two parameters related to the first ICG inflow into the brain (P=0.04; P=0.01). This is likely related to the reduction of cerebral perfusion following TBI. Significant changes in ICG optical properties minutes after injection (P=0.04) were registered. The acquisition of valid optical data in a clinical environment was challenging.

Conclusions

Future research should analyze abnormalities in the ICG kinetic following brain trauma, test how these values can enhance care in TBI, and adapt the current optical devices to clinical settings. Also, studies on the pattern in changes of ICG optical properties after venous injection can improve the accuracy of the values detected.

Item Type:	Article
Additional Information:	This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects:	WL Nervous system. Neurology WN Medical imaging. Radiology
Divisions:	Emergency Services > Neurology Planned IP Care > General Surgery
Related URLs:	https://pubmed.ncbi.nlm.nih.gov/33139989...
Depositing User:	Mrs Yolande Brookes
Date Deposited:	18 Nov 2020 14:04
Last Modified:	18 Nov 2020 14:04
URI:	http://www.repository.uhblibrary.co.uk/id/eprint/3665

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