Noninvasive Instrument-based Tests for Detecting and Measuring Vitreous Inflammation in Uveitis: A Systematic Review.

Liu, Xiaoxuan, Hui, Benjamin Tk, Way, Christopher, Beese, Sophie, Adriano, Ada, Keane, Pearse A, Moore, David J and Denniston, Alastair K (2020) Noninvasive Instrument-based Tests for Detecting and Measuring Vitreous Inflammation in Uveitis: A Systematic Review. Ocular immunology and inflammation. pp. 1-12. ISSN 1744-5078.

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Abstract

PURPOSE

This systematic review aims to identify instrument-based tests for quantifying vitreous inflammation in uveitis, report the test reliability and the level of correlation with clinician grading.

METHODS

Studies describing instrument-based tests for detecting vitreous inflammation were identified by searching bibliographic databases and trials registers. Test reliability measures and level of correlation with clinician vitreous haze grading are extracted.

RESULTS

Twelve studies describing ultrasound, optical coherence tomography (OCT), and retinal photography for detecting vitreous inflammation were included: Ultrasound was used for detection of disease features, whereas OCT and retinal photography provided quantifiable measurements. Correlation with clinician grading for OCT was 0.53-0.60 (three studies) and for retinal photography was 0.51 (1 study). Both instruments showed high inter- and intra-observer reliability (>0.70 intraclass correlation and Cohen's kappa), where reported in four studies.

CONCLUSION

Retinal photography and OCT are able to detect and measure vitreous inflammation. Both techniques are reliable, automatable, and warrant further evaluation.

Item Type: Article
Subjects: WN Medical imaging. Radiology
WW Eyes. Ophthalmology
Divisions: Ambulatory Care > Ophthalmology
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Depositing User: Mrs Yolande Brookes
Date Deposited: 20 Nov 2020 11:58
Last Modified: 20 Nov 2020 11:58
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3683

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