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Perry, Richard J, Smith, Craig J, Roffe, Christine, Simister, Robert, Narayanamoorthi, Saravanan, Marigold, Richard, Willmot, Mark, Dixit, Anand, Hassan, Ahamad, Quinn, Terence J, Ankolekar, Sandeep, Zhang, Liqun, Banerjee, Soma, Ahmed, Urwah, Padmanabhan, Nishita, Ferdinand, Phillip, McGrane, Frances, Banaras, Azra, Marks, Isobel H and Werring, David J (2020) Characteristics and outcomes of COVID-19 associated stroke: a UK multicentre case-control study. Journal of neurology, neurosurgery, and psychiatry. ISSN 1468-330X. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Full text not available from this repository.Abstract
OBJECTIVE
We set out to determine which characteristics and outcomes of stroke are associated with COVID-19.
METHODS
This case-control study included patients admitted with stroke to 13 hospitals in England and Scotland between 9 March and 5 July 2020. We collected data on 86 strokes (81 ischaemic strokes and 5 intracerebral haemorrhages) in patients with evidence of COVID-19 at the time of stroke onset (cases). They were compared with 1384 strokes (1193 ischaemic strokes and 191 intracerebral haemorrhages) in patients admitted during the same time period who never had evidence of COVID-19 (controls). In addition, the whole group of stroke admissions, including another 37 patients who appeared to have developed COVID-19 after their stroke, were included in two logistic regression analyses examining which features were independently associated with COVID-19 status and with inpatient mortality.
RESULTS
Cases with ischaemic stroke were more likely than ischaemic controls to occur in Asians (18.8% vs 6.7%, p<0.0002), were more likely to involve multiple large vessel occlusions (17.9% vs 8.1%, p<0.03), were more severe (median National Institutes of Health Stroke Scale score 8 vs 5, p<0.002), were associated with higher D-dimer levels (p<0.01) and were associated with more severe disability on discharge (median modified Rankin Scale score 4 vs 3, p<0.0001) and inpatient death (19.8% vs 6.9%, p<0.0001). Recurrence of stroke during the patient's admission was rare in cases and controls (2.3% vs 1.0%, NS).
CONCLUSIONS
Our data suggest that COVID-19 may be an important modifier of the onset, characteristics and outcome of acute ischaemic stroke.
| Item Type: | Article |
|---|---|
| Additional Information: | This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs |
| Subjects: | WG Cardiovascular system. Cardiology WL Nervous system. Neurology |
| Divisions: | Emergency Services > Neurology |
| Related URLs: | |
| Depositing User: | Jamie Edgar |
| Date Deposited: | 23 Nov 2020 11:30 |
| Last Modified: | 23 Nov 2020 11:30 |
| URI: | http://www.repository.uhblibrary.co.uk/id/eprint/3703 |
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