Safety and efficacy of transurethral resection of bladder tumour comparing spinal anaesthesia to spinal anaesthesia with an obturator nerve block: a systematic review and meta-analysis.

Krishan, Anil, Bruce, Angus, Khashaba, Shehab, Abouelela, Mohamed and Ehsanullah, Syed Ali (2020) Safety and efficacy of transurethral resection of bladder tumour comparing spinal anaesthesia to spinal anaesthesia with an obturator nerve block: a systematic review and meta-analysis. Journal of endourology. ISSN 1557-900X. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

Aims To investigate whether spinal anaesthesia with an obturator nerve block (SA+ONB) can be effectively employed for TURBT during the COVID-19 pandemic to improve patient outcomes whilst also avoiding aerosol-generating procedures. We aimed to compare outcomes of transurethral resection of bladder tumours (TURBT) using spinal anaesthesia (SA) alone versus SA+ONB in terms of rates of obturator reflex, bladder perforation, incomplete tumour resection, tumour recurrence and local anaesthetic toxicity. Methods We conducted a comprehensive search of electronic databases (MEDLINE, PUBMED, EMBASE, CINAHL, CENTRAL, SCOPUS, Google Scholar and Web of Science), identifying studies comparing the outcomes of TURBT using spinal anaesthesia versus spinal with an obturator nerve block. The Cochrane risk-of-bias tool for RCTs and the Newcastle-Ottawa scale for observational studies were used to assess the included studies. Random effects modelling was used to calculate pooled outcome data. Results Four randomised control trials (RCTs) and three cohort studies were identified, enrolling a total of 448 patients. The use of spinal anaesthesia with an obturator nerve block was associated with a significantly reduced risk of obturator reflex (P<0.00001), bladder perforation (P=0.02), incomplete resection (P<0.0001) and 12-month tumour recurrence (P=0.005). Obturator nerve block was not associated with an increased risk of local anaesthetic toxicity (0/159). Conclusion Our meta-analysis suggests that TURBT employing spinal anaesthesia with an obturator nerve block is superior to the use of spinal anaesthesia alone. During the COVID-19 pandemic, where avoidance of aerosol-generating procedures (AGPs) such as a general anaesthesia is paramount, the use of an obturator nerve block with spinal anaesthesia is essential for the safety of both patients and staff without compromising care. Further high-quality RCTs with adequate sample sizes are required to compare the different techniques of obturator nerve block as well as comparing this method to general anaesthesia with complete neuromuscular blockade.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WJ Urogenital system. Urology
WO Surgery
WO Surgery > WO500 Anaesthesia
Divisions: Planned IP Care > Urology
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 30 Nov 2020 11:38
Last Modified: 30 Nov 2020 11:38
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3738

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