Preventing tuberculosis in paediatric kidney transplant recipients: is there a role for BCG immunisation pre-transplantation in low tuberculosis incidence countries?

Bamford, Alasdair, Dixon, Garth, Klein, Nigel, Marks, Stephen D, Ritz, Nicole, Welch, Steven B and Tebruegge, Marc (2020) Preventing tuberculosis in paediatric kidney transplant recipients: is there a role for BCG immunisation pre-transplantation in low tuberculosis incidence countries? Pediatric nephrology (Berlin, Germany). ISSN 1432-198X. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: http://link.springer.com/journal/467

Abstract

The risk of tuberculosis (TB) disease is increased in children with chronic kidney disease (CKD), even higher in stage 5 CKD/kidney failure and especially high after kidney transplantation due to immunosuppression. TB disease may follow recent primary infection, or result from reactivation of latent infection. Reactivation is more common in adults, while progression following primary infection makes up a greater proportion of disease in children. Recommendations for preventing TB disease in some low TB incidence countries have previously included offering Bacillus Calmette-Guérin (BCG) vaccine to all children listed for kidney transplant if they had not received this as part of previous national immunisation programmes. Based on the available evidence, we recommend modifying this practice, focusing instead on awareness of risk factors for TB exposure, infection and disease and the use of appropriate testing strategies to identify and treat TB infection and disease.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QW Microbiology. Immunology
WC Communicabable diseases
WS Paediatrics. Child health
Divisions: Womens and Childrens > Paediatrics
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Depositing User: Jamie Edgar
Date Deposited: 07 Dec 2020 14:41
Last Modified: 07 Dec 2020 14:41
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3766

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