Seeking international consensus on approaches to primary tumour treatment in Ewing sarcoma.

Gerrand, Craig, Bate, Jessica, Seddon, Beatrice, Dirksen, Uta, Randall, R Lor, van de Sande, Michiel, O'Donnell, Paul, Tuckett, John, Peake, David, Jeys, Lee, Saifuddin, Asif, Grainger, Mel and Whelan, Jeremy (2020) Seeking international consensus on approaches to primary tumour treatment in Ewing sarcoma. Clinical sarcoma research, 10 (1). p. 21. ISSN 2045-3329.

[img]
Preview
Text
Seeking international consensus on approaches to primary tumour treatment in Ewing sarcoma.pdf

Download (1MB) | Preview
Official URL: https://clinicalsarcomaresearch.biomedcentral.com/...

Abstract

BACKGROUND

The local treatment of Ewing sarcoma of bone involves surgery, radiotherapy or both. The selection of treatment depends on the anatomical extent of the tumour, the effectiveness of the proposed treatment, its morbidity, and the expectation of cure. However, not only are there variations in the approach to local treatment between individual patients, but also between treatment centres and countries. Our aim was to explore variation in practice and develop consensus statements about local treatment.

METHODS

A three stage modified Delphi technique was used with international collaborators. This involved an expert panel to identify areas of controversy, an online survey of international collaborators and a consensus meeting in London, UK in June 2017. In the consensus meeting, teams of clinicians discussed the local management of selected cases and their responses were collected with electronic voting.

RESULTS

Areas of greater or less consensus were identified. The lack of evidence underpinning different approaches was noted and areas for collaborative research became apparent.

CONCLUSION

This has demonstrated that there is an international consensus around many aspects of the local treatment of Ewing sarcoma of bone, including the use of specialist MultiDisciplinary Team (MDT) meetings with access to all appropriate treatments. However, considerable variation remains including the use of different staging investigations, decision making, definitions of response, and radiotherapy doses and timing. Further collaborative work should be undertaken to determine the impact of these variations in order to define best practice.

Item Type: Article
Subjects: WE Musculoskeletal. Orthopaedics
Divisions: Planned IP Care > Trauma and Orthopaedics
Womens and Childrens > Paediatrics
Related URLs:
Depositing User: Mr Philip O'Reilly
Date Deposited: 11 Dec 2020 15:14
Last Modified: 11 Dec 2020 15:14
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3779

Actions (login required)

View Item View Item