Ixazomib, lenalidomide, and dexamethasone is effective and well tolerated in multiply relapsed (≥2nd relapse) refractory myeloma: a multicenter real world UK experience.

Maouche, Nadjoua, Kishore, Bhuvan, Jenner, Matthew W, Boyd, Kevin, Bhatti, Zara, Bird, Sarah Anne, Chander, Gurvin, Robinson, Rebecca, Vallance, Grant D, Offer, Mark, Kothari, Jaimal, Peniket, Andy, Aitchison, Robin, Dungarwalla, Moez, Collings, Freya, Bygrave, Ceri and Ramasamy, Karthik (2020) Ixazomib, lenalidomide, and dexamethasone is effective and well tolerated in multiply relapsed (≥2nd relapse) refractory myeloma: a multicenter real world UK experience. Leukemia & lymphoma. pp. 1-9. ISSN 1029-2403. Full text available via OpenAthens for UHB Athens account holders.

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Official URL: https://www.tandfonline.com/doi/abs/10.1080/104281...

Abstract

There are limited real world data on ixazomib, lenalidomide, and dexamethasone (IRd) in multiply relapsed myeloma. We analyzed outcomes of 116 patients who received IRd predominantly at second and subsequent relapse including those refractory to proteasome inhibitors (PIs). With a median follow up 16.3 months, the overall response rate was 66.9%; median progression-free survival (PFS) was 17.7 months with median overall survival (OS) not reached (NR). PFS and OS were significantly shorter in advanced disease (PFS; 12.6 vs. 21.2 months ( = .01), OS; 15.9 months vs. NR ( = .01) for ISS3 vs. ISS 1&2, respectively). PFS and OS were significantly shorter in clinical high risk (CHR) compared to standard risk (SR) patients (PFS; 9.3 months vs. NR ( = .001), OS; 11.5 months vs. NR ( < .001), respectively). There was a trend toward shorter PFS in PI-refractory patients 13.7 vs. 19.6 months for non-PI refractory ( = .2). The triplet combination was generally well tolerated.

Item Type: Article
Additional Information: Full text available via OpenAthens for UHB Athens account holders.
Subjects: WH Haemic and lymphatic systems. Haematology
Divisions: Planned IP Care > Oncology and Clinical Haematology
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Depositing User: Mr Philip O'Reilly
Date Deposited: 13 Jan 2021 12:35
Last Modified: 13 Jan 2021 12:35
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3837

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