Breastfeeding promotes early neonatal regulatory T cell expansion and immune tolerance of non-inherited maternal antigens.

Wood, H L, Acharjee, Animesh, Pearce, H, Quraishi, M N, Powell, R M, Rossiter, A E, Beggs, A D, Ewer, A K, Moss, Paul and Toldi, G (2021) Breastfeeding promotes early neonatal regulatory T cell expansion and immune tolerance of non-inherited maternal antigens. Allergy. ISSN 1398-9995. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

Full text not available from this repository.
Official URL: http://onlinelibrary.wiley.com/journal/10.1111/(IS...

Abstract

BACKGROUND

Breastfeeding is associated with long-term health benefits, such as a lower incidence of childhood infections, asthma, obesity and autoimmune disorders. However, little is known regarding how the maternal and neonatal immune systems interact after parturition when the neonate receives nutrition from maternal breastmilk.

METHODS

We undertook a comparative analysis of immune repertoire and function at birth and 3 weeks of age in a cohort of 38 term neonates born by caesarean section grouped according to feeding method (breastmilk versus formula). We used flow cytometry to study the immune phenotype in neonatal and maternal blood samples and mixed lymphocyte reactions to establish the proliferation response of neonatal versus maternal lymphocytes and vice versa. The microbiome of neonatal stool samples was also investigated using 16S rRNA sequencing.

RESULTS

We show that the proportion of regulatory T cells (Tregs) increases in this period and is nearly two-fold higher in exclusively breastfed neonates compared to those who received formula milk only. Moreover, breastfed neonates show a specific and Treg-dependent reduction in proliferative T cell responses to non-inherited maternal antigens (NIMA), associated with a reduction in inflammatory cytokine production. We also observed the enrichment of short chain fatty acid producing taxa (Veillonella and Gemella) in stool samples of exclusively breastfed neonates.

CONCLUSIONS

These data indicate that exposure of the neonate to maternal cells through breastfeeding acts to drive the maturation of Tregs and 'tolerizes' the neonate towards NIMA.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QW Microbiology. Immunology
QZ Pathology. Oncology
WO Surgery
WS Paediatrics. Child health
Divisions: Womens and Childrens > Neonates
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 18 Jan 2021 15:19
Last Modified: 18 Jan 2021 15:19
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3857

Actions (login required)

View Item View Item