Factors associated with frequent exacerbations in the UK Severe Asthma Registry.

Yang, Freda, Busby, John, Heaney, Liam G, Menzies-Gow, Andrew, Pfeffer, Paul E, Jackson, David J, Mansur, Adel H, Siddiqui, Salman, Brightling, Christopher E, Niven, Robert, Thomson, Neil C and Chaudhuri, Rekha (2021) Factors associated with frequent exacerbations in the UK Severe Asthma Registry. The journal of allergy and clinical immunology. In practice. ISSN 2213-2201.

Full text not available from this repository.
Official URL: 10.1016/j.jaip.2020.12.062.

Abstract

BACKGROUND

Frequent exacerbations are an important cause of morbidity in patients with severe asthma.

OBJECTIVE

Our aim was to identify factors associated with frequent exacerbations in a large well-characterized severe asthma population and determine whether factors differed in patients treated with and without maintenance oral corticosteroids (OCS).

METHODS

Adults with severe asthma from specialized asthma centers across the UK were recruited to the UK Severe Asthma Registry (UKSAR). Demography, co-morbidities and physiological measurements were collected. We conducted univariable and multivariable logistic regression analyses to identify factors associated with frequent exacerbations, defined as ≥3 exacerbations treated with high-dose systemic corticosteroids in the past year.

RESULTS

Of 1592 patients with severe asthma from the UKSAR, 1137 (71%) were frequent exacerbators (FE) and 833 (52%) were on maintenance OCS. FE were more likely to be ex-smokers, have gastroesophageal reflux disease (GERD), higher Asthma Control Questionnaire-6 (ACQ-6) score and blood eosinophilia. Multivariable regression analyses showed ACQ-6 score >1.5 (OR 4.25, p<0.001), past smoking history (OR 1.55, p=0.024) and FeNO >50ppb (OR 1.54, p=0.044) were independently associated with frequent exacerbations. Past smoking history correlated with frequent exacerbations only in patients on maintenance OCS (OR 2.25, p=0.004), whereas ACQ-6 score >1.5 was independently associated with frequent exacerbations in those treated with and without maintenance OCS (OR 2.74, p=0.017 and OR 6.42, p<0.001, respectively).

CONCLUSION

Several factors were associated with frequent exacerbations in a large UK severe asthma registry population. High ACQ-6 score had the strongest association with frequent exacerbations irrespective of maintenance OCS status.

Item Type: Article
Subjects: WF Respiratory system. Respiratory medicine
Divisions: Planned IP Care > Respiratory Medicine
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Depositing User: Mrs Caroline Tranter
Date Deposited: 27 Jan 2021 09:16
Last Modified: 27 Jan 2021 09:16
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3905

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