Total Body Photography for the Diagnosis of Cutaneous Melanoma in Adults: A Systematic Review and Meta-Analysis.

Ji-Xu, A, Dinnes, J and Matin, R N (2020) Total Body Photography for the Diagnosis of Cutaneous Melanoma in Adults: A Systematic Review and Meta-Analysis. The British journal of dermatology. ISSN 1365-2133. (In Press) This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs.

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Official URL: https://onlinelibrary.wiley.com/doi/10.1111/bjd.19...

Abstract

BACKGROUND

Early detection of melanoma is essential to reduce mortality. Total body photography (TBP) can facilitate the detection of melanoma in high-risk individuals. However, the accuracy of TBP in diagnosing melanoma remains unclear.

OBJECTIVES

To determine the diagnostic accuracy of TBP for the detection of melanoma in adults.

METHODS

MEDLINE, EMBASE, Cochrane, and Centre for Reviews databases were searched from inception to 26 May 2020. Studies using TBP for diagnosing melanoma with at least one follow-up appointment were eligible if they provided data to calculate at least one diagnostic accuracy measure. Two authors independently screened articles, extracted data, and assessed quality. Disagreements were resolved by a third reviewer.

RESULTS

Ten studies were included, comprising 41703 patients who underwent TBP and 6203 biopsies. Melanoma in situ (MIS) was diagnosed in 315 (5.1%) lesions and invasive melanoma in 187 (3.0%) lesions biopsied. Summary estimates for TBP in diagnosing melanoma were calculated: mean percentage of biopsies positive for MIS or melanoma was 16% (95% CI, 11%-20%), NNB was 8.6 (range 2.3-19.6), naevus:melanoma ratio was 7.6 (range 1.3-18.6), and MIS:melanoma ratio was 1.7 (1.0-3.5). Regression analysis showed a negative correlation between NNB and MIS:melanoma ratio.

CONCLUSIONS

Available data regarding the diagnostic accuracy of TBP are heterogeneous, due to variability in the risk profile of cohorts and TBP protocols. Best current estimates suggest that TBP for diagnosing melanoma has an acceptable NNB in high-risk patients. However, prospective diagnostic test accuracy studies are needed to accurately gauge the diagnostic accuracy of TBP.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs.
Subjects: QZ Pathology. Oncology
WN Medical imaging. Radiology
WR Skin. Dermatology
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Depositing User: Mrs Noomi Tyholdt-Pidgley
Date Deposited: 29 Jan 2021 10:07
Last Modified: 29 Jan 2021 10:07
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3920

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