Management of fatigue with physical activity and behavioural change support in vasculitis: a feasibility study.

Harper, Lorraine, Hewitt, Catherine A, Litchfield, Ian, Morgan, Matthew D, Chanouzas, Dimitrios, Caulfield, Hollie K, Coughlan, Linda, Dean, Caroline, Fletcher, Kate, Cramp, Fiona, Greenfield, Sheila, Ives, Natalie J, Jowett, Sue, Kodabuckus, Shalela, Tearne, Sarah, Sehmi, Sukhwant, Edwardson, Charlotte, Dawkins, Nathan P and Daley, Amanda J (2020) Management of fatigue with physical activity and behavioural change support in vasculitis: a feasibility study. Rheumatology (Oxford, England). ISSN 1462-0332. (In Press) This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs.

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Abstract

OBJECTIVE

Patients with ANCA associated vasculitis (AAV) experience high levels of fatigue, despite disease remission. This study assessed the feasibility and acceptability of a definitive randomised controlled trial of a behavioural-based physical activity intervention to support fatigue self-management in AAV patients.

METHODS

AAV patients in disease remission with fatigue (Multidimensional Fatigue Inventory-20 general fatigue domain ≥) were randomly allocated to intervention or standard care in this single-centre open-label randomised controlled feasibility study. The intervention lasted 12 weeks and comprised eight face-to-face physical activity sessions with a facilitator and 12 weekly telephone calls. Participants were encouraged to monitor their physical activity using a tracker device (Fitbit). Standard care involved sign-posting to fatigue websites. The primary outcome was feasibility of a phase III trial assessed against three stop-go traffic light criteria, (recruitment, intervention adherence and study withdrawal). A qualitative study assessed participant views about the intervention.

RESULTS

248 patients were screened and 134 were eligible to participate (54%). Stop-go criteria were amber for recruitment; 43/134 (32%, 95% CI 24-40) eligible participants randomised, amber for adherence; 73% of participants attended all eight physical activity sessions, but only 11/22 (50%, 95% CI 29-71%) completed the intervention as per the intended schedule, and green for study withdrawal; 2/43 participants withdrew before 24 weeks (5%, 95% CI 0-11). Qualitative results suggested the intervention was acceptable.

CONCLUSION

This study suggests a behavioural-based physical activity intervention targeting fatigue self-management was acceptable to patients with AAV, although recruitment and protocol adherence will need modification prior to a definitive trial. Clinical Trial Registration Number ISRCTN11929227.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs.
Subjects: WD Diseases and disorders of systemic, metabolic or environmental origin > WD350 Immunologic diseases
WH Haemic and lymphatic systems. Haematology
Divisions: Clinical Support
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Depositing User: Mrs Noomi Tyholdt-Pidgley
Date Deposited: 29 Jan 2021 10:07
Last Modified: 29 Jan 2021 10:07
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3921

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