Primary mesenteric sarcomas: Collaborative experience from the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG).

Tattersall, Hannah L, Hodson, James, Cardona, Kenneth, Lee, Rachel M, Nessim, Carolyn, Gladdy, Rebecca, Van Der Hage, Jos, Schrage, Yvonne, Tseng, William W, van Houdt, Winan, Novak, Marko, Grignani, Giovanni, Tolomeo, Francesco, Goel, Neha, Ryon, Emily, Gyorki, David, Bagaria, Sanjay P, Gonzalez, Jose A, Arnau, Ana B M, Sayyed, Raza, Tirotta, Fabio, Evenden, Caroline, Desai, Anant, Almond, Max, Glasbey, James, Fiore, Marco, Gronchi, Alessandro and Ford, Samuel J (2020) Primary mesenteric sarcomas: Collaborative experience from the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG). Journal of surgical oncology. ISSN 1096-9098. (In Press) This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs.

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Official URL: https://onlinelibrary.wiley.com/doi/10.1002/jso.26...

Abstract

BACKGROUND

Primary mesenteric soft tissue sarcomas (STS) are rare and limited evidence is available to inform management. Surgical resection is challenging due to the proximity of vital structures and a need to preserve enteric function.

OBJECTIVES

To determine the overall survival (OS) and recurrence-free survival (RFS) for patients undergoing primary resection for mesenteric STS.

METHODS

The Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) is an intercontinental collaborative comprising specialist sarcoma centers. Data were collected retrospectively for all patients with mesenteric STS undergoing primary resection between 2000 and 2019.

RESULTS

Fifty-six cases from 15 institutions were included. The spectrum of pathology was similar to the retroperitoneum, although of a higher grade. R0/R1 resection was achieved in 87%. Median OS was 56 months. OS was significantly shorter in higher-grade tumors (p = .018) and extensive resection (p < .001). No significant association between OS and resection margin or tumor size was detected. Rates of local recurrence (LR) and distant metastases (DM) at 5 years were 60% and 41%, respectively. Liver metastases were common (60%), reflecting portal drainage of the mesentery.

CONCLUSION

Primary mesenteric sarcoma is rare, with a modest survival rate. LR and DM are frequent events. Liver metastases are common, highlighting the need for surveillance imaging.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs.
Subjects: QZ Pathology. Oncology
WO Surgery
Divisions: Clinical Support
Planned IP Care
Related URLs:
Depositing User: Mrs Noomi Tyholdt-Pidgley
Date Deposited: 12 Feb 2021 16:48
Last Modified: 12 Feb 2021 16:48
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3922

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