Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review.

Subramanian, Anuradhaa, Idkowiak, Jan, Toulis, Konstantinos A, Thangaratinam, Shakila, Arlt, Wiebke and Nirantharakumar, Krishnarajah (2021) Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review. European journal of endocrinology, 184 (1). pp. 51-64. ISSN 1479-683X.

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Abstract

Context

The incidence of gestational diabetes mellitus (GDM) has been on the rise, driven by maternal obesity. In parallel, pubertal tempo has increased in the general population, driven by childhood obesity.

Objective

To evaluate the available evidence on pubertal timing of boys and girls born to mothers with GDM.

Data sources

We searched MEDLINE, EMBASE, CINAHL Plus, Cochrane library and grey literature for observational studies up to October 2019.

Study selection and extraction

Two reviewers independently selected studies, collected data and appraised the studies for risk of bias. Results were tabulated and narratively described as reported in the primary studies.

Results

Seven articles (six for girls and four for boys) were included. Study quality score was mostly moderate (ranging from 4 to 10 out of 11). In girls born to mothers with GDM, estimates suggest earlier timing of pubarche, thelarche and menarche although for each of these outcomes only one study each showed a statistically significant association. In boys, there was some association between maternal GDM and earlier pubarche, but inconsistency in the direction of shift of age at onset of genital and testicular development and first ejaculation. Only a single study analysed growth patterns in children of mothers with GDM, describing a 3-month advancement in the age of attainment of peak height velocity and a slight increase in pubertal tempo.

Conclusions

Pubertal timing may be influenced by the presence of maternal GDM, though current evidence is sparse and of limited quality. Prospective cohort studies should be conducted, ideally coupled with objective biochemical tests.

Item Type: Article
Subjects: W Public health. Health statistics. Occupational health. Health education
WD Diseases and disorders of systemic, metabolic or environmental origin > WD10 Diet and nutrition
WD Diseases and disorders of systemic, metabolic or environmental origin > WD250 Metabolic diseases
WK Endocrine system. Endocrinology
Divisions: Ambulatory Care > Diabetes
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Depositing User: Jamie Edgar
Date Deposited: 04 Feb 2021 12:20
Last Modified: 04 Feb 2021 12:20
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3944

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