Optimal management of acute kidney injury in critically ill patients with invasive fungal infections being treated with liposomal amphotericin B.

Armstrong-James, Darius, Koh, Mickey, Ostermann, Marlies and Cockwell, Paul (2020) Optimal management of acute kidney injury in critically ill patients with invasive fungal infections being treated with liposomal amphotericin B. BMJ case reports, 13 (5). ISSN 1757-790X. Available through UHB Open Athens

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Official URL: https://casereports.bmj.com/content/13/5/e233072.l...

Abstract

Critically ill patients are at risk of developing both acute kidney injury (AKI) and invasive fungal infections (IFIs). Prompt and efficient treatment of the IFI is essential for the survival of the patient. This article examines three distinct clinical situations where liposomal amphotericin B, a broad-spectrum antifungal agent, was successfully used in the setting of AKI. The first was infection in a 63-year-old man with bleeding oesophageal varices related to advanced liver disease. The second was gastrointestinal mucormycosis in a 74-year-old man who developed a small bowel obstruction following an autologous stem cell transplant for mantle cell lymphoma. The third was a infection in a 32-year-old woman on immunosuppression for a bilateral lung transplant for cystic fibrosis. In all three cases, liposomal amphotericin B was required for urgent management of the patient's IFI. We discuss the rationale for treatment with a potentially nephrotoxic agent in this setting.

Item Type: Article
Additional Information: Available through UHB Open Athens
Subjects: WB Practice of medicine > WB400 Intensive care
WC Communicabable diseases
WJ Urogenital system. Urology
Divisions: Clinical Support > Critical Care
Clinical Support > Infectious Diseases
Emergency Services > Renal
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Depositing User: Beth Connors
Date Deposited: 04 Feb 2021 15:40
Last Modified: 18 Feb 2021 12:27
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3947

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