Management of Allogeneic Stem Cell Transplantation for High-Risk AML following SARS-CoV-2 Associated Pancytopenia with Marked Bone Marrow Biopsy Alterations.

Kaparou, Maria, Rudzki, Zbigniew, Giles, Hannah, Murthy, Vidhya, Srinath, Swathy, Lloyd, Rebecca, Ahmed, Maria Zahid, Salhan, Beena, Chauhan, Saleena, Kishore, Bhuvan, Lovell, Richard, Horgan, Claire, Paneesha, Shankara, Xenou, Evgenia, Lokare, Anand, Ewing, Joanne, Dassanayake, Hansini, Nikolousis, Emmanouil and Kanellopoulos, Alexandros Georgios (2021) Management of Allogeneic Stem Cell Transplantation for High-Risk AML following SARS-CoV-2 Associated Pancytopenia with Marked Bone Marrow Biopsy Alterations. Case reports in hematology, 2021. p. 8843063. ISSN 2090-6560. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

The present study describes a patient aged 70 with very high-risk AML who successfully received a nonmyeloablative matched unrelated donor allograft shortly following SARS-CoV-2 infection, which manifested with mild cough, interstitial abnormalities on chest CT, and pancytopenia with profound bone marrow biopsy histological alterations. In parallel, our study provides bone marrow biopsy data in a series of contemporary patients with serious haematological diseases who had a bone marrow biopsy performed within two weeks of PCR confirmation of SARS-CoV-2 infection. This study is notable because there are no published data describing the bone marrow biopsy changes observed in patients with haematological malignancies and SARS-CoV-2 infection. Finally, it is suggested that nonmyeloablative hematopoietic stem cell transplantation for very high-risk haematological malignancies can be successfully performed following recovery from SARS-CoV-2 infection.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WH Haemic and lymphatic systems. Haematology
Divisions: Planned IP Care > Oncology and Clinical Haematology
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Depositing User: Jamie Edgar
Date Deposited: 10 Feb 2021 10:35
Last Modified: 10 Feb 2021 10:35
URI: http://www.repository.uhblibrary.co.uk/id/eprint/3961

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