Tools
Tools
Wraith, David C and Krishna, Mamidipudi T (2021) Peptide allergen-specific immunotherapy for allergic airway diseases-State of the art. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. ISSN 1365-2222. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
|
Text (PDF file format)
C&E Allergy.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (572kB) | Preview |
Abstract
Allergen-specific immunotherapy (AIT) is the only means of altering the natural immunological course of allergic diseases and achieving long-term remission. Pharmacological measures are able to suppress the immune response and/or ameliorate the symptoms but there is a risk of relapse soon after these measures are withdrawn. Current AIT approaches depend on the administration of intact allergens, often comprising crude extracts of the allergen. We propose that the challenges arising from current approaches, including the risk of serious side-effects, burdensome duration of treatment, poor compliance and high cost, are overcome by application of peptides based on CD4 T cell epitopes rather than whole allergens. Here we describe evolving approaches, summarize clinical trials involving peptide AIT in allergic rhinitis and asthma, discuss the putative mechanisms involved in their action, address gaps in evidence and propose future directions for research and clinical development.
| Item Type: | Article |
|---|---|
| Additional Information: | This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs |
| Subjects: | WD Diseases and disorders of systemic, metabolic or environmental origin WF Respiratory system. Respiratory medicine |
| Divisions: | Clinical Support > Immunology |
| Related URLs: | |
| Depositing User: | Mrs Yolande Brookes |
| Date Deposited: | 26 Feb 2021 12:24 |
| Last Modified: | 26 Feb 2021 12:24 |
| URI: | http://www.repository.uhblibrary.co.uk/id/eprint/4031 |
Actions (login required)
 |
View Item |
