Bio-chemo-mechanics of the thoracic aorta.

Iddawela, Sashini, Ravendren, Andrew and Harky, Amer (2021) Bio-chemo-mechanics of the thoracic aorta. Vascular biology (Bristol, England), 3 (1). R25-R33. ISSN 2516-5658. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

The pathophysiology of thoracic aortic aneurysm and dissection is poorly understood, despite high mortality. An evidence review was conducted to examine the biomechanical, chemical and genetic factors involved in thoracic aortic pathology. The composition of connective tissue and smooth muscle cells can mediate important mechanical properties that allow the thoracic aorta to withstand and transmit pressures. Genetic syndromes can affect connective tissue and signalling proteins that interrupt smooth muscle function, leading to tissue failure. There are complex interplaying factors that maintain thoracic aortic function in health and are disrupted in disease, signifying an area for extensive research.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WF Respiratory system. Respiratory medicine
WG Cardiovascular system. Cardiology
Divisions: Planned IP Care > Respiratory Medicine
Related URLs:
Depositing User: Mrs Yolande Brookes
Date Deposited: 11 Mar 2021 15:53
Last Modified: 11 Mar 2021 15:53
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4082

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