Supportive care in the acute phase of Stevens-Johnson syndrome and toxic epidermal necrolysis: an international, multidisciplinary DELPHI-based consensus.

Brüggen, M-C, Le, S T, Walsh, S, Toussi, A, de Prost, N, Ranki, A, Didona, B, Colin, A, Horváth, B, Brezinova, E, Milpied, B, Moss, C, Bodemer, C, Meyersburg, D, Salavastru, C, Tiplica, G-S, Howard, E, Bequignon, E, Bouwes Bavinck, J N, Newman, J, Gueudry, J, Nägeli, M, Zaghbib, K, Pallesen, K, Bygum, A, Joly, P, Wolkenstein, P, Chua, S-L, Le Floch, R, Shear, N H, Chu, C-Y, Hama, N, Abe, R, Chung, W-H, Shiohara, T, Arden-Jones, M, Romanelli, P, Phillips, E J, Stern, R S, Cotliar, J, Micheletti, R G, Brassard, A, Schulz, J T, Dodiuk-Gad, R P, Dominguez, A R, Paller, A S, Vidal, L S, Mostaghimi, A, Noe, M H, Worswick, S, Tartar, D, Sheridan, R, Kaffenberger, B H, Shinkai, K, Maverakis, E, French, L E and Ingen-Housz-Oro, S (2021) Supportive care in the acute phase of Stevens-Johnson syndrome and toxic epidermal necrolysis: an international, multidisciplinary DELPHI-based consensus. The British journal of dermatology. ISSN 1365-2133. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Abstract

BACKGROUND

Supportive care is the cornerstone of adult and pediatric management of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). However, consensus on the modalities of supportive care is lacking.

OBJECTIVES

Our aim in this international multicentric Delphi exercise was to establish a multidisciplinary expert consensus to standardize recommendations regarding supportive care in the acute phase of SJS/TEN.

METHODS

Participants were sent a survey via the online tool "Survey Monkey" consisting of 103 statements organized into 11 topics: multidisciplinary team composition, suspect drug management, infection prevention, fluid resuscitation and prevention of hypothermia, nutritional support, pain and psychological distress management, management of acute respiratory failure, local skin care, ophthalmological management, management of other mucosa, and additional measures. Participants evaluated the level of appropriateness of each statements on a scale of 1 (extremely inappropriate) to 9 (extremely appropriate). Results were analyzed according to the RAND/UCLA Appropriateness Method.

RESULTS

Forty-five participants from 13 countries (3 continents) participated. After the first round, a consensus was obtained for 84% of the 103 initially proposed statements. After the second round, a final consensus was obtained for 102 statements.

CONCLUSIONS

We have reached an international Delphi-based consensus on best supportive care practice for SJS/TEN. Our expert consensus should help guide physicians in treating patients with SJS/TEN and thereby improve short-term prognosis and the risk of sequelae.

Item Type:	Article
Additional Information:	This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects:	WR Skin. Dermatology
Divisions:	Ambulatory Care > Dermatology
Related URLs:	https://pubmed.ncbi.nlm.nih.gov/33657677...
Depositing User:	Mrs Yolande Brookes
Date Deposited:	11 Mar 2021 16:28
Last Modified:	11 Mar 2021 16:28
URI:	http://www.repository.uhblibrary.co.uk/id/eprint/4084

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