Nephrotic syndrome secondary to alpha-1 antitrypsin deficiency.

Santos, Gabriela F, Ellis, Paul, Farrugia, Daniela and Turner, Alice M (2021) Nephrotic syndrome secondary to alpha-1 antitrypsin deficiency. BMJ case reports, 14 (3). ISSN 1757-790X. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: http://casereports.bmj.com/

Abstract

We report a 64-year-old caucasian woman diagnosed with membranous nephropathy secondary to alpha-1 antitrypsin deficiency (AATD). AATD is a rare autosomal codominant genetic disorder. Its clinical manifestations are mostly observed in the lungs, with early-onset emphysema. Nephropathy due to AATD is still very rare and only a few cohort studies have been reported. It has been recognised that alpha-1 antitrypsin has a protective role in the kidneys which enhances the possibility of development of kidney failure, such as nephrotic syndrome, in cases of AATD. Further clinical investigation is needed to understand the relationship between the development of nephropathy, namely membranous nephropathy, and AATD.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WF Respiratory system. Respiratory medicine
WJ Urogenital system. Urology
Divisions: Planned IP Care > Respiratory Medicine
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Depositing User: Jamie Edgar
Date Deposited: 18 Mar 2021 11:07
Last Modified: 18 Mar 2021 11:07
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4105

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