How and when to use CSF to investigate neonates and children with possible central nervous system infection.

Winzor, Gemma and Atabani, Sowsan F (2021) How and when to use CSF to investigate neonates and children with possible central nervous system infection. Archives of disease in childhood. Education and practice edition. ISSN 1743-0593. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: https://ep.bmj.com/

Abstract

A child presented to the emergency department with fever, reduced consciousness, irritability and reduced oral intake. Infective meningitis and encephalitis were within the differential diagnoses. Is a lumbar puncture (LP) indicated and, if so, what is the optimal timing of LP? Will antimicrobial pretreatment affect the cerebrospinal fluid (CSF) results? How can clinicians optimise diagnostic stewardship to benefit individual patients and society at large? Interpretation of rapidly available CSF biochemical tests (protein, glucose and lactate levels) and microscopy can provide a prompt insight into the infective aetiology and inform treatment and further diagnostic testing strategies. Diagnosis of an aetiological pathogen in a patient presenting with central nervous system (CNS) infection has clinical, infection control and public health implications. A plethora of tests are available to enable CSF analysis in patients with possible CNS infection. We aimed to summarise current evidence and guidance to ensure the best possible use of the diagnostics available.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QW Microbiology. Immunology
W Public health. Health statistics. Occupational health. Health education
Divisions: Emergency Services > Acute Medicine and AMU
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 30 Mar 2021 10:01
Last Modified: 30 Mar 2021 10:01
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4149

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