Morbidity and Outcomes After Distal Pancreatectomy for Primary Retroperitoneal Sarcoma: An Analysis by the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group.

Bagaria, Sanjay P, Swallow, Carol, Suraweera, Harini, Raut, Chandrajit P, Fairweather, Mark, Cananzi, Ferdinando, Quagliuolo, Vittorio, Grignani, Giovanni, Hompes, Daphne, Ford, Samuel J, Nessim, Carolyn, Apte, Sameer, Skoczylas, Jacek, Rutkowski, Piotr, Bonvalot, Sylvie, Tzanis, Dimitri, Gabriel, Emmanuel, Pennacchioli, Elisabetta, Albertsmeier, Markus, Canter, Robert J, Pollock, Raphael, Grignol, Valerie, Cardona, Kenneth, Gamboa, Adriana C, Novak, Marko, Stoeckle, Eberhard, Almquist, Martin, Ahuja, Nita, Klemen, Nicholas, Van Houdt, Winan, Gyorki, David, Gangi, Alexandra, Rastrelli, Marco, van der Hage, Jos, Schrage, Yvonne, Valeri, Sergio, Conti, Lorenzo, Spiegel, Matthew R, Li, Zhou, Fiore, Marco and Gronchi, Alessandro (2021) Morbidity and Outcomes After Distal Pancreatectomy for Primary Retroperitoneal Sarcoma: An Analysis by the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group. Annals of surgical oncology. ISSN 1534-4681. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: http://link.springer.com/journal/10434

Abstract

BACKGROUND

Multi-visceral resection often is used in the treatment of retroperitoneal sarcoma (RPS). The morbidity after distal pancreatectomy for primary pancreatic cancer is well-documented, but the outcomes after distal pancreatectomy for primary RPS are not. This study aimed to evaluate morbidity and oncologic outcomes after distal pancreatectomy for primary RPS.

METHODS

In this study, 26 sarcoma centers that are members of the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) retrospectively identified consecutive patients who underwent distal pancreatectomy for primary RPS from 2008 to 2017. The outcomes measured were 90-day severe complications (Clavien-Dindo ≥ 3), postoperative pancreatic fistula (POPF) rate, and oncologic outcomes.

RESULTS

Between 2008 and 2017, 280 patients underwent distal pancreatectomy for primary RPS. The median tumor size was 25 cm, and the median number of organs resected, including the pancreas, was three. In 96% of the operations, R0/R1 resection was achieved. The 90-day severe complication rate was 40 %. The grades B and C POPF complication rates were respectively 19% and 5% and not associated with worse overall survival. Administration of preoperative radiation and factors to mitigate POPF did not have an impact on the risk for the development of a POPF. The RPS invaded the pancreas in 38% of the patients, and local recurrence was doubled for the patients who had a microscopic, positive pancreas margin (hazard ratio, 2.0; p = 0.042).

CONCLUSION

Distal pancreatectomy for primary RPS has acceptable morbidity and oncologic outcomes and is a reasonable approach to facilitate complete tumor resection.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QZ Pathology. Oncology
WO Surgery
WR Skin. Dermatology
Divisions: Planned IP Care > General Surgery
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 30 Mar 2021 10:09
Last Modified: 30 Mar 2021 10:09
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4150

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