Emerging therapies and their delivery for treating age-related macular degeneration.

Thomas, Chloe N, Sim, Dawn A, Lee, Wen Hwa, Alfahad, Nada, Dick, Andrew D, Denniston, Alastair K and Hill, Lisa J (2021) Emerging therapies and their delivery for treating age-related macular degeneration. British journal of pharmacology. ISSN 1476-5381. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: http://onlinelibrary.wiley.com/journal/10.1111/(IS...

Abstract

Age-related macular degeneration (AMD) is the most common cause of blindness in the Western world and is characterised in its latter stages by retinal cell death and neovascularisation and earlier stages with the loss of parainflammatory homeostasis. Patients with neovascular AMD (nAMD) are treated with frequent intraocular injections of anti-vascular endothelial growth factor (VEGF) therapies, which are not only unpopular with patients, but carry risks of sight-threatening complications. A minority of patients are unresponsive with no alternative treatment available and some patients who respond initially eventually develop a tolerance to treatment. New therapeutics with improved delivery methods and sustainability of clinical effects are required, in particular for non-neovascular AMD (90% of cases and no current approved treatments). There are age-related and disease-related changes that occur which can affect ocular drug delivery. Here, we review the latest emerging therapies for AMD, their delivery routes, and implications for translating to clinical practice.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QT Human physiology
W Public health. Health statistics. Occupational health. Health education
WT Geriatrics. Elderly care
WW Eyes. Ophthalmology
Divisions: Ambulatory Care > Ophthalmology
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 08 Apr 2021 11:14
Last Modified: 08 Apr 2021 11:14
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4177

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