Endoscopic transsphenoidal surgery reconstruction using the fibrin sealant patch Tachosil.

Jolly, Karan, Gupta, Keshav Kumar, Egbuji, Ofuchi, Naik, Paresh Pramod and Ahmed, Shahzada Khuram (2021) Endoscopic transsphenoidal surgery reconstruction using the fibrin sealant patch Tachosil. British journal of neurosurgery. pp. 1-10. ISSN 1360-046X. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: http://informahealthcare.com/journal/bjn/

Abstract

INTRODUCTION

The incidence of CSF leak following endoscopic transsphenoidal surgery remains the most important measure in the success of any repair. The nasoseptal flap (NSF) has played a pivotal role in reconstructing defects. However, morbidity associated with the NSF includes bleeding, septal injury, altered smell and crusting. Tachosil is an absorbable fibrin sealant patch that promotes haemostasis and wound healing. The purpose of this study was to evaluate the effectiveness of Tachosil to repair intraoperative defects during an endoscopic transsphenoidal approach.

MATERIALS AND METHODS

All patients who underwent an endoscopic transsphenoidal approach with the use of Tachosil at the Queen Elizabeth Hospital Birmingham, between January 2013 and June 2020 were retrospectively analysed. Tachosil was used as an overlay patch over of the bony defect, in a multi-layered repair depending on the defect and grade of CSF leak. The primary outcome measure was post-operative CSF leak.

RESULTS

A total of 52 primary procedures where Tachosil was used as the overlay were analysed. There were 23 (44.2%) intraoperative CSF leaks. The overall post-operative CSF leak rate was 7.8% ( = 4), with all cases having had a Tachosil overlay reconstruction with no NSF. A formal NSF was harvested in only five cases alongside the Tachosil patch, where a grade 2 or more leak was identified at the time of the primary procedure, none of which developed a post-operative leak. No patient had any post-operative adverse outcomes that were attributed to Tachosil.

CONCLUSIONS

We believe this to be the largest case series evaluating the endoscopic use of Tachosil in skull base reconstruction. Our data show that in endoscopic transsphenoidal approach, Tachosil may be used safely in a multi-layered approach as an effective alternative to the NSF in low flow CSF leak cases, or alongside a NSF in higher flow leaks.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WV Otorhinolaryngology. ENT medicine
Divisions: Ambulatory Care > ENT
Related URLs:
Depositing User: Jamie Edgar
Date Deposited: 08 Apr 2021 11:28
Last Modified: 08 Apr 2021 11:28
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4178

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