Epidemiology and mortality of Cushing's syndrome.

Hakami, Osamah A, Ahmed, Shahzada and Karavitaki, Niki (2021) Epidemiology and mortality of Cushing's syndrome. Best practice & research. Clinical endocrinology & metabolism. p. 101521. ISSN 1878-1594.

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Abstract

Endogenous Cushing's syndrome (CS) is a rare endocrine disorder characterised by excess cortisol secretion due to either ACTH-dependent conditions [commonly an ACTH-producing pituitary adenoma (Cushing's disease)] or ACTH-independent causes (with most common aetiology being a benign adrenal adenoma). Overall, the annual incidence of CS ranges between 1.8 and 3.2 cases per million population. Mortality in active CS is elevated compared to the general population, and a number of studies support the view that survival is also compromised even after apparent successful treatment. The main cause of death is cardiovascular disease highlighting the negative impact of cortisol excess on cardiovascular risk factors. Early diagnosis and prompt treatment of the cortisol excess, as well as vigilant monitoring and stringent control of cardiovascular risk factors are key elements for the long-term prognosis of these patients.

Item Type: Article
Subjects: WD Diseases and disorders of systemic, metabolic or environmental origin
WD Diseases and disorders of systemic, metabolic or environmental origin > WD250 Metabolic diseases
WK Endocrine system. Endocrinology
WV Otorhinolaryngology. ENT medicine
Divisions: Ambulatory Care > Endocrinology
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Depositing User: Jamie Edgar
Date Deposited: 08 Apr 2021 13:56
Last Modified: 08 Apr 2021 13:56
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4182

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