The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.

Friščić, Jasna, Böttcher, Martin, Reinwald, Christiane, Bruns, Heiko, Wirth, Benjamin, Popp, Samantha-Josefine, Walker, Kellie Irene, Ackermann, Jochen A, Chen, Xi, Turner, Jason, Zhu, Honglin, Seyler, Lisa, Euler, Maximilien, Kirchner, Philipp, Krüger, René, Ekici, Arif B, Major, Triin, Aust, Oliver, Weidner, Daniela, Fischer, Anita, Andes, Fabian T, Stanojevic, Zeljka, Trajkovic, Vladimir, Herrmann, Martin, Korb-Pap, Adelheid, Wank, Isabel, Hess, Andreas, Winter, Johnathan, Wixler, Viktor, Distler, Jörg, Steiner, Günter, Kiener, Hans P, Frey, Benjamin, Kling, Lasse, Raza, Karim, Frey, Silke, Kleyer, Arnd, Bäuerle, Tobias, Hughes, Timothy R, Grüneboom, Anika, Steffen, Ulrike, Krönke, Gerhard, Croft, Adam P, Filer, Andrew, Köhl, Jörg, Klein, Kerstin, Buckley, Christopher D, Schett, Georg, Mougiakakos, Dimitrios and Hoffmann, Markus H (2021) The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts. Immunity. ISSN 1097-4180.

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Official URL: https://www.cell.com/immunity/fulltext/S1074-7613(...

Abstract

Arthritis typically involves recurrence and progressive worsening at specific predilection sites, but the checkpoints between remission and persistence remain unknown. Here, we defined the molecular and cellular mechanisms of this inflammation-mediated tissue priming. Re-exposure to inflammatory stimuli caused aggravated arthritis in rodent models. Tissue priming developed locally and independently of adaptive immunity. Repeatedly stimulated primed synovial fibroblasts (SFs) exhibited enhanced metabolic activity inducing functional changes with intensified migration, invasiveness and osteoclastogenesis. Meanwhile, human SF from patients with established arthritis displayed a similar primed phenotype. Transcriptomic and epigenomic analyses as well as genetic and pharmacological targeting demonstrated that inflammatory tissue priming relies on intracellular complement C3- and C3a receptor-activation and downstream mammalian target of rapamycin- and hypoxia-inducible factor 1α-mediated metabolic SF invigoration that prevents activation-induced senescence, enhances NLRP3 inflammasome activity, and in consequence sensitizes tissue for inflammation. Our study suggests possibilities for therapeutic intervention abrogating tissue priming without immunosuppression.

Item Type: Article
Subjects: WD Diseases and disorders of systemic, metabolic or environmental origin > WD350 Immunologic diseases
WD Diseases and disorders of systemic, metabolic or environmental origin > WD811 Rheumatology
Divisions: Ambulatory Care > Rheumatology
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Depositing User: Mrs Caroline Tranter
Date Deposited: 13 Apr 2021 09:12
Last Modified: 13 Apr 2021 09:12
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4192

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