British Rhinological Society Consensus Guidance on the use of biological therapies for Chronic Rhinosinusitis with Nasal Polyps.

Hopkins, Claire, McKenzie, Jo-Lyn, Anari, Shahram, Carrie, Sean, Ramakrishnan, Yujay, Kara, Naveed, Philpott, Carl, Hobson, Jonathan, Qureishi, Ali, Stew, Ben, Bhalla, Raj, Gane, Simon, Walker, Abigail, Harries, Phil, Hathorn, Iain and Lund, Valerie (2021) British Rhinological Society Consensus Guidance on the use of biological therapies for Chronic Rhinosinusitis with Nasal Polyps. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery. ISSN 1749-4486. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: http://onlinelibrary.wiley.com/journal/10.1111/(IS...

Abstract

OBJECTIVES

We set out to create Consensus Guidelines, based on current evidence and relative risks of adverse effects and the costs of different treatments, that reflect the views of the British Rhinological Society (BRS) Council on where the use of biologics should be positioned within treatment pathways for CRSwNP, specifically in the setting of the National Health Service (NHS).

DESIGN

An expert panel of 16 members was assembled. A review of the literature and evidence synthesis was undertaken and circulated to the panel We used the RAND/UCLA methodology with a multi-step process to make recommendations on the use of biologics.

SETTING

N/A PARTICIPANTS: N/A RESULTS: Recommendations were made, based on underlying disease severity, prior treatments and co-morbidities. A group of patients for whom biologics were considered an appropriate treatment option for CRSwNP was defined.

CONCLUSIONS

Although biologics are not currently available for the treatment of CRSwNP, the BRS Council have defined a group of patients who have higher rates of 'failure' with current treatment pathways, higher resource use and are more likely to suffer with uncontrolled symptoms. We would urge NICE to consider approval of biologics for such indications without applying further restrictions on use.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WV Otorhinolaryngology. ENT medicine
Divisions: Ambulatory Care > ENT
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Depositing User: Jamie Edgar
Date Deposited: 14 Apr 2021 09:47
Last Modified: 14 Apr 2021 09:47
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4196

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