The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells.

Jahangiri, Leila, Ishola, Tala, Pucci, Perla, Trigg, Ricky M, Pereira, Joao, Williams, John A, Cavanagh, Megan L, Gkoutos, Georgios V, Tsaprouni, Loukia and Turner, Suzanne D (2021) The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells. Cancers, 13 (6). ISSN 2072-6694. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: http://www.mdpi.com/journal/cancers

Abstract

Cancer stem cells (CSCs) possess properties such as self-renewal, resistance to apoptotic cues, quiescence, and DNA-damage repair capacity. Moreover, CSCs strongly influence the tumour microenvironment (TME) and may account for cancer progression, recurrence, and relapse. CSCs represent a distinct subpopulation in tumours and the detection, characterisation, and understanding of the regulatory landscape and cellular processes that govern their maintenance may pave the way to improving prognosis, selective targeted therapy, and therapy outcomes. In this review, we have discussed the characteristics of CSCs identified in various cancer types and the role of autophagy and long noncoding RNAs (lncRNAs) in maintaining the homeostasis of CSCs. Further, we have discussed methods to detect CSCs and strategies for treatment and relapse, taking into account the requirement to inhibit CSC growth and survival within the complex backdrop of cellular processes, microenvironmental interactions, and regulatory networks associated with cancer. Finally, we critique the computationally reinforced triangle of factors inclusive of CSC properties, the process of autophagy, and lncRNA and their associated networks with respect to hypoxia, epithelial-to-mesenchymal transition (EMT), and signalling pathways.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: QZ Pathology. Oncology
W Public health. Health statistics. Occupational health. Health education
WL Nervous system. Neurology
WO Surgery
Divisions: Planned IP Care > Oncology and Clinical Haematology
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Depositing User: Jamie Edgar
Date Deposited: 15 Apr 2021 10:11
Last Modified: 15 Apr 2021 10:11
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4207

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