Development of central precocious puberty following cannabinoid use for paediatric epilepsy: causal or coincidence?

Krishnan, Aditya, Agwu, Juliana Chizo, Kallappa, Chetana and Pandey, Rajesh (2021) Development of central precocious puberty following cannabinoid use for paediatric epilepsy: causal or coincidence? BMJ case reports, 14 (4). ISSN 1757-790X. This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs

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Official URL: http://casereports.bmj.com/

Abstract

Research suggests a role for cannabidiol oil in managing certain forms of paediatric onset epilepsy. However, studies on the impact of cannabis on the hypothalamo-pituitary-gonadal (HPG) axis have conflicting results. Delta-9-tetrahydrocannabinol (Δ9-THC) acutely inhibits gonadotropin-releasing hormone in the hypothalamus, reducing testosterone levels by 65% in rhesus monkeys. Additionally, there have been reports of pubertal arrest and delayed puberty in male cannabis users. In contrast, other studies have reported higher testosterone levels following long-term cannabis use.A 2-year-old boy presented with testicular enlargement, increased penile length and growth of coarse pubic hair developing over 6 months. His mother procured cannabidiol oil online, which he started taking 7 months earlier for severe epilepsy refractory to medical management. Subsequent investigations confirmed central precocious puberty. While it is unclear whether the precocious puberty is a direct consequence of HPG axis activation by Δ9-THC, this case demonstrates a temporal association between cannabis use and development of precocious puberty.

Item Type: Article
Additional Information: This article is available to all UHB staff and students via ASK Discovery tool http://tinyurl.com/z795c8c by using their UHB Athens login IDs
Subjects: WK Endocrine system. Endocrinology
WS Paediatrics. Child health
Divisions: Ambulatory Care > Endocrinology
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Depositing User: Jamie Edgar
Date Deposited: 23 Apr 2021 15:21
Last Modified: 23 Apr 2021 15:21
URI: http://www.repository.uhblibrary.co.uk/id/eprint/4249

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